Vuorinen V, Sallinen P, Haapasalo H, Visakorpi T, Kallio M, Jääskeläinen J
Department of Neurosurgery, University of Helsinski, Finland.
Acta Neurochir (Wien). 1996;138(12):1399-408. doi: 10.1007/BF01411118.
Cell proliferation indices of 31 primary intracranial haemangiopericytomas (HPC) and their recurrences and metastases were correlated with the long-term recurrence, metastasis and survival rates. Paraffin-embedded specimens were used for K-67, PCNA and p53 immunostainings and for estimation of S-phase fraction (S-PF) in flow cytometry. The median Ki-67 and PCNA indices and S-PFs were 10.4, 3.2, and 4.0 for primary HPCs and 14.1, 14.1, and 5.5 for recurrences, respectively. High indices were associated with higher recurrence, metastasis and death rates, but not at the p < or = 0.5 level. Consequently, these indices do not seem useful in planning of treatment and follow-up of meningeal HPCs. Meningeal HPCs, in contrast to meningiomas, recur almost always despite seemingly complete removal and often metastasize elsewhere in the body. This difference between two sharply demarcated tumours must reflect particularly adhesive and infiltrative properties of HPC cells and not just higher proliferation potential.
31例原发性颅内血管外皮细胞瘤（HPC）及其复发和转移灶的细胞增殖指数与长期复发、转移及生存率相关。石蜡包埋标本用于K-67、PCNA和p53免疫染色以及流式细胞术检测S期细胞分数（S-PF）。原发性HPC的Ki-67和PCNA指数中位数以及S-PF分别为10.4、3.2和4.0，而复发病灶分别为14.1、14.1和5.5。高指数与较高的复发、转移和死亡率相关，但在p≤0.5水平时并非如此。因此，这些指数在脑膜HPC的治疗规划和随访中似乎并无用处。与脑膜瘤不同，脑膜HPC几乎总会复发，尽管看似已完全切除，且常发生远处转移。这两种界限分明的肿瘤之间的差异一定特别反映了HPC细胞的黏附性和浸润性，而不仅仅是更高的增殖潜能。
