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Prevention of simian immunodeficiency virus, SIVsm, or HIV-2 infection in cynomolgus monkeys by pre- and postexposure administration of BEA-005.

作者信息

Böttiger D, Johansson N G, Samuelsson B, Zhang H, Putkonen P, Vrang L, Oberg B

机构信息

Microbiology and Tumour Biology Centre, Karolinska Institute, Stockholm, Sweden.

出版信息

AIDS. 1997 Feb;11(2):157-62. doi: 10.1097/00002030-199702000-00004.

DOI:10.1097/00002030-199702000-00004
PMID:9030361
Abstract

OBJECTIVE

To study the possibilities and limitations of postexposure treatment to prevent the establishment of infection after accidental exposure to HIV.

DESIGN AND METHODS

The effect of 2,3'-dideoxy-3'-hydroxymethyl cytidine (B1 A-005) was investigated on acute simian immunodeficiency virus (SIV) and HIV-2 infections in macaques in pre- and postexposure treatment experiments.

RESULTS

Postexposure treatment with BLA-005 (3 x 10 mg/kg) for as short as 3 days prevented infection with SIVsm after intravenous or rectal inoculation. Infection with HIV-2 could also be blocked by postexposure BFA-005 treatment.

CONCLUSION

This study shows that therapeutic intervention can block early systemic and mucosal infections with SIV and HIV-2. Further evaluation is ongoing.

摘要

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