Chaillan F A, Marchetti E, Delfosse F, Roman F S, Soumireu-Mourat B
Laboratoire de Neurobiologie des Comportements-URA 372 CNRS Université de Provence-IBHOP, Marseille, France.
Behav Brain Res. 1997 Jan;82(2):203-12. doi: 10.1016/s0166-4328(97)80990-4.
In this study, the functional properties of the dorsomedial prefrontal cortex (dmPFC) of the rat were examined in two olfactory tasks. In a successive cue olfactory discrimination task, dmPFC lesioned animals improved performance across sessions more rapidly than operated control animals. In an olfactory task using fixed interval training, animals with similar lesions were impaired. Both effects, although opposite, can be explained by a temporal processing deficit. The present results seem to indicate that the dmPFC is required for timing, classified as part of non-declarative memory. As reference memory improved in the lesioned animals, the finding is that the dmPFC supports non-declarative memory and thus interacts with declarative memory in the long-term formation of the associations between a particular stimulus (olfactory cue) and particular responses.
在本研究中，在两项嗅觉任务中检测了大鼠背内侧前额叶皮质（dmPFC）的功能特性。在连续线索嗅觉辨别任务中，dmPFC损伤的动物比手术对照动物在各实验环节中表现改善得更快。在使用固定间隔训练的嗅觉任务中，具有类似损伤的动物表现受损。这两种效应虽然相反，但都可以用时间处理缺陷来解释。目前的结果似乎表明，dmPFC是计时所必需的，计时被归类为非陈述性记忆的一部分。由于损伤动物的参考记忆得到改善，研究结果是dmPFC支持非陈述性记忆，因此在特定刺激（嗅觉线索）与特定反应之间关联的长期形成过程中与陈述性记忆相互作用。
