Maggio D, Pacifici R, Cherubini A, Simonelli G, Luchetti M, Aisa M C, Cucinotta D, Adami S, Senin U
Department of Gerontology and Geriatrics, University of Perugia, Italy.
Calcif Tissue Int. 1997 Jan;60(1):94-7. doi: 10.1007/s002239900193.
In order to evaluate in vivo the entity of endosteal and periosteal changes with age in the two sexes, and their relative contribution to age-related cortical bone loss, we undertook a cross-sectional study on a population of normal Caucasian subjects. The group included 189 women and 107 men who were studied by photodensitometry and radiogrammetry of the second metacarpal bone, derived from the same standard hand X-ray. Of the subjects, 134 were 65 years of age or older (75 women and 59 men). Metacarpal bone mineral density (BMD) correlated with age in both sexes, with an annual bone loss rate of 0.5% in women and 0.15% in men. In the over 65 group, correlation was significant only in women, who underwent an acceleration in the rate of bone loss (1% per year). Marrow cavity width (M), cortical index at the second metacarpal shaft (MI) and external width (W) all correlated with age in both sexes, although generally better in the female than in the male sex. M almost doubled from the fourth to the ninth decade in women and increased 50% in men. In the same age interval, MI showed an annual decrease of 0.49% in females and 0.33% in males. In the over 65 group, cortical thinning rate was significant in women (0.39% per annum) but not in men (0.14% per annum), whereas correlation of W was not significant in either sex. Finally, MI correlated with BMD in the whole study population and in the over 65, with a female prevalence in correlation strength maintained throughout life. The following conclusions can be derived for metacarpal aging: (1) an acceleration in cortical bone loss occurs in females after age 65; (2) age-related growth in periosteal diameter, although significant in the whole population, is negligible in the elderly of both sexes; (3) age-related cortical bone loss is generally more dependent on cortical thinning in women than in men.
为了在体内评估两性中骨内膜和骨膜变化随年龄的情况，以及它们对与年龄相关的皮质骨丢失的相对贡献，我们对一组正常白种人进行了一项横断面研究。该组包括189名女性和107名男性，通过对同一标准手部X线片上的第二掌骨进行光密度测定和放射测量来进行研究。其中，134名受试者年龄在65岁及以上（75名女性和59名男性）。两性的掌骨骨密度（BMD）均与年龄相关，女性的年骨丢失率为0.5%，男性为0.15%。在65岁以上组中，仅女性的相关性显著，其骨丢失率加速（每年1%）。骨髓腔宽度（M）、第二掌骨干的皮质指数（MI）和外部宽度（W）在两性中均与年龄相关，尽管通常女性比男性的相关性更好。女性从第四到第九个十年，M几乎翻倍，男性增加50%。在相同年龄区间内，女性的MI每年下降0.49%，男性下降0.33%。在65岁以上组中，女性的皮质变薄率显著（每年0.39%），而男性不显著（每年0.14%），而W在两性中的相关性均不显著。最后，在整个研究人群和65岁以上人群中，MI与BMD相关，且在整个生命过程中女性的相关性强度占优势。对于掌骨老化可得出以下结论：（1）65岁后女性皮质骨丢失加速；（2）与年龄相关的骨膜直径增加，尽管在整个人口中显著，但在两性老年人中可忽略不计；（3）与年龄相关的皮质骨丢失通常女性比男性更依赖于皮质变薄。
