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Prodynorphin, proenkephalin and kappa opioid receptor mRNA responses to acute "binge" cocaine.

作者信息

Spangler R, Zhou Y, Maggos C E, Schlussman S D, Ho A, Kreek M J

机构信息

Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10021, USA.

出版信息

Brain Res Mol Brain Res. 1997 Feb;44(1):139-42. doi: 10.1016/s0169-328x(96)00249-5.

DOI:10.1016/s0169-328x(96)00249-5
PMID:9030708
Abstract

Previous studies showed that preprodynorphin (ppDyn) mRNA increases in caudate-putamen while kappa opioid receptor (KOR) mRNA decreases in substantia nigra after 3 and 14 days "binge" cocaine. To further characterize opioid mRNA responses, rats were administered: saline; 1 day cocaine followed by 1 day saline; 1 day cocaine; or 2 days cocaine. ppDyn mRNA in caudate-putamen increased in both groups receiving cocaine on the final day compared to groups receiving saline. Preproenkephalin (ppEnk) mRNA in caudate-putamen increased, and KOR mRNA in substantia nigra decreased, after 2 days of cocaine. Thus ppDyn mRNA is elevated acutely by cocaine, while ppEnk and KOR mRNAs show a significant response only on the second day of "binge" cocaine.

摘要

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