Montes A, Hervás F, Jolin T
Horm Res. 1977;8(3):148-58. doi: 10.1159/000178793.
Plasma growth hormone and insulin levels were measured in normal, thyroidectomized (TX), and TX rats treated with 1-thyroxine (1-T4) or rat-growth hormone (r-GH). Although normal growth was observed 5 days after surgery, a decrease of circulating levels of GH was evidenced as early as 5 days after the operation. However, the plasma insulin levels were not affected by the 5th, 10th and 15th day of thyroidectomy. With a more prolonged thyroid hormone deprivation, the plasma insulin levels of TX rats remained lower than those of age-paired controls. Treatment of hypothyroid rats with 0.05 micron 1-T4 for 10 days induced growth and an increase in circulating GH levels, but had no effect on the low levels of plasma insulin of TX rats. Treatment of TX animals with 0.10 or 0.20 micron 1-T4, or 100 micron r-GH during 10 days caused plasma insulin levels to shift toward the values of their weight-paired controls. However, treatment of hypophysectomized (HX) rats with 0.20 micron T4 during 8 days did not change the circulating levels of plasma insulin. It is suggested that thyroid hormone deprivation results in a decrease of circulating levels of insulin secondary to a deficiency in growth hormone secretion. In addition, normal GH secretion appears to be required for normal pancreatic insulin secretion to occur.
在正常大鼠、甲状腺切除（TX）大鼠以及用1-甲状腺素（1-T4）或大鼠生长激素（r-GH）处理的TX大鼠中测量了血浆生长激素和胰岛素水平。尽管术后5天观察到正常生长，但早在手术后5天就已证明循环中的生长激素水平有所下降。然而，甲状腺切除术后第5天、第10天和第15天血浆胰岛素水平未受影响。随着甲状腺激素缺乏时间延长，TX大鼠的血浆胰岛素水平仍低于年龄匹配的对照组。用0.05微克1-T4治疗甲状腺功能减退大鼠10天可诱导生长并使循环中的生长激素水平升高，但对TX大鼠的低血浆胰岛素水平没有影响。在10天内用0.10或0.20微克1-T4或100微克r-GH治疗TX动物会使血浆胰岛素水平向体重匹配对照组的值转变。然而，用0.20微克T4治疗垂体切除（HX）大鼠8天并未改变血浆胰岛素的循环水平。提示甲状腺激素缺乏继发于生长激素分泌不足导致循环中胰岛素水平下降。此外，正常的生长激素分泌似乎是正常胰腺胰岛素分泌发生所必需的。
