Babadjanova G, Allolio B, Beuschlein F, Chuchalin A, Reincke M
Schwerpunkt Endokrinologie, Medizinische Universitätsklinik Würzburg,Germany.
Metabolism. 1997 Feb;46(2):121-2. doi: 10.1016/s0026-0495(97)90287-0.
Recently, a polymorphism in the glycogen synthase gene was shown to be associated with the development of non-insulin-dependent diabetes mellitus (NIDDM) and identified patients with a strong family history of diabetes and hypertension in the Finnish population. However, no association was found in French and Japanese populations. We investigated the possible association between the XbaI polymorphism of the glycogen synthase gene and NIDDM in the Russian population. One hundred fifty NIDDM patients and 109 healthy controls were studied. In 16 of 150 Russian NIDDM patients (10.7%), the XbaI polymorphism was found, and 17 of 109 controls (15.6%) showed the XbaI polymorphism (P > .05). These results suggest that the XbaI polymorphism of the glycogen synthase gene cannot be used as a marker for NIDDM in the Russian population.
最近，糖原合酶基因中的一种多态性被证明与非胰岛素依赖型糖尿病（NIDDM）的发生有关，并在芬兰人群中识别出有糖尿病和高血压家族病史的患者。然而，在法国和日本人群中未发现相关性。我们研究了俄罗斯人群中糖原合酶基因XbaI多态性与NIDDM之间的可能关联。研究了150例NIDDM患者和109例健康对照。在150例俄罗斯NIDDM患者中的16例（10.7%）发现了XbaI多态性，109例对照中的17例（15.6%）显示有XbaI多态性（P>.05）。这些结果表明，糖原合酶基因的XbaI多态性不能用作俄罗斯人群中NIDDM的标志物。
