Kuroyama H, Sanke T, Nanjo K
First Department of Medicine, Wakayama University of Medical Science.
Nihon Rinsho. 1994 Oct;52(10):2726-30.
As glycogen synthase is a key enzyme of the non-oxidative pathway of glucose metabolism in the skeletal muscle, and reduced activity of this enzyme is related to insulin resistance, it seems likely that this enzyme is a candidate gene for contributing to the pathogenesis of NIDDM. In this paper, we review recent findings of polymorphism of the human glycogen synthase gene, XbaI restriction enzyme length polymorphism and simple tandem repeat DNA polymorphism, and discuss the possible association between the glycogen synthase gene and NIDDM.
由于糖原合酶是骨骼肌中葡萄糖代谢非氧化途径的关键酶，且该酶活性降低与胰岛素抵抗有关，因此该酶似乎有可能是导致非胰岛素依赖型糖尿病发病机制的候选基因。在本文中，我们综述了人类糖原合酶基因多态性、XbaI限制性酶切长度多态性和简单串联重复DNA多态性的最新研究结果，并讨论了糖原合酶基因与非胰岛素依赖型糖尿病之间可能存在的关联。
