Yamashita N, Kaneoka H, Kaneko S, Takeno M, Oneda K, Koizumi H, Kogure M, Inaba G, Sakane T
Department of Immunology, St Marianna University School of Medicine, Kanagawa, Japan.
Clin Exp Immunol. 1997 Feb;107(2):241-7. doi: 10.1111/j.1365-2249.1997.274-ce1159.x.
Phenotypic and functional properties of gammadelta T cells, which play an important role in mucocutaneous immunity, were examined to elucidate whether immunological abnormality in Behcet's disease may be related to a specific T cell population. We found that CD45RA+ Vgamma9+ Vdelta2+ gammadelta T cells, which constitute a minor population of gammadelta T cells in healthy individuals, were increased in number in Behçet's disease irrespective of disease activity. This CD45RA+ subset of gammadelta T cells in the active, but not inactive, phase of this disease expressed IL-2Rbeta and HLA-DR, suggesting that they are activated in vivo in active Behçet's disease. In addition, the CD45RA+ gammadelta T cells produced extreme amounts of tumour necrosis factor and contained perforin granules. These data indicate that a phenotypically distinct subset of gammadelta T cells, CD45RA+ CD45RO- Vgamma9+ Vdelta2+, may contribute to immunological abnormalities which may lead to complexity of pathophysiology in Behçet's disease.
在黏膜皮肤免疫中发挥重要作用的γδT细胞的表型和功能特性被进行了检测，以阐明白塞病的免疫异常是否可能与特定的T细胞群体有关。我们发现，CD45RA+Vγ9+Vδ2+γδT细胞（在健康个体中构成γδT细胞的一个小群体）在白塞病中数量增加，与疾病活动无关。在该疾病的活动期而非非活动期，这种γδT细胞的CD45RA+亚群表达IL-2Rβ和HLA-DR，这表明它们在活动期白塞病中在体内被激活。此外，CD45RA+γδT细胞产生大量肿瘤坏死因子并含有穿孔素颗粒。这些数据表明，γδT细胞的一个表型不同的亚群，即CD45RA+CD45RO-Vγ9+Vδ2+，可能导致免疫异常，这可能导致白塞病病理生理学的复杂性。
