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免疫细胞在白塞病中的作用。

The roles of immune cells in Behçet's disease.

作者信息

Hu Dan, Guan Jian-Long

机构信息

Department of Rheumatology and Immunology, Huadong Hospital affiliated with Fudan University, #221 Yan'an West Road, Shanghai, 200040, P.R. China.

出版信息

Adv Rheumatol. 2023 Oct 9;63(1):49. doi: 10.1186/s42358-023-00328-w.

Abstract

Behçet's disease (BD) is a systemic vasculitis that can affect multiple systems, including the skin, mucous membranes, joints, eyes, gastrointestinal and nervous. However, the pathogenesis of BD remains unclear, and it is believed that immune-inflammatory reactions play a crucial role in its development. Immune cells are a critical component of this process and contribute to the onset and progression of BD. By regulating the function of these immune cells, effective control over the occurrence and development of BD can be achieved, particularly with regards to monocyte activation and aggregation, macrophage differentiation and polarization, as well as T cell subset differentiation. This review provides a brief overview of immune cells and their role in regulating BD progression, which may serve as a theoretical foundation for preventing and treating this disease.

摘要

白塞病(BD)是一种可累及多个系统的全身性血管炎,这些系统包括皮肤、黏膜、关节、眼睛、胃肠道和神经系统。然而,白塞病的发病机制仍不清楚,人们认为免疫炎症反应在其发展过程中起着关键作用。免疫细胞是这一过程的关键组成部分,对白塞病的发生和发展有影响。通过调节这些免疫细胞的功能,可以有效控制白塞病的发生和发展,特别是在单核细胞激活和聚集、巨噬细胞分化和极化以及T细胞亚群分化方面。本综述简要概述了免疫细胞及其在调节白塞病进展中的作用,这可能为预防和治疗该疾病提供理论基础。

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