放疗后喉骨肉瘤：病例报告及文献综述
Postirradiation laryngeal osteosarcoma: case report and literature review.
作者信息
Sheen T S, Wu C T, Hsieh T, Hsu M M
机构信息
Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
出版信息
Head Neck. 1997 Jan;19(1):57-62. doi: 10.1002/(sici)1097-0347(199701)19:1<57::aid-hed11>3.0.co;2-o.
BACKGROUND
Laryngeal sarcoma is a rare disease entity. In review of the literature, chondrosarcoma is the most common sarcoma, followed by fibrosarcoma. Osteosarcoma is very rare; there are only seven cases reported in the literature. Postirradiation sarcoma is a late complication of radiotherapy. Osteosarcoma is the most common type in this group. The larynx is often involved in the radiation field of treatment for head and neck malignancies. However, postirradiation laryngeal osteosarcoma has not yet been reported.
METHODS
We present a 56-year-old man who under went radiotherapy for nasopharyngeal carcinoma 32 years ago and later developed a laryngeal osteosarcoma.
RESULTS
The patient underwent total laryngectomy but died 1 year and 9 months later with locally extensive disease.
CONCLUSIONS
We report the first case of postirradiation laryngeal osteosarcoma. In addition to surgical treatment, adjunctive therapies should be considered for this group of patients.
背景
喉肉瘤是一种罕见的疾病实体。在文献回顾中，软骨肉瘤是最常见的肉瘤，其次是纤维肉瘤。骨肉瘤非常罕见；文献中仅报道了7例。放疗后肉瘤是放射治疗的晚期并发症。骨肉瘤是该组中最常见的类型。喉部常位于头颈部恶性肿瘤的放射治疗野内。然而，放疗后喉骨肉瘤尚未见报道。
方法
我们报告一名56岁男性，32年前因鼻咽癌接受放疗，后来发生了喉骨肉瘤。
结果
患者接受了全喉切除术，但1年9个月后因局部广泛病变死亡。
结论
我们报告了首例放疗后喉骨肉瘤病例。对于这类患者，除手术治疗外，还应考虑辅助治疗。
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