Teo Wan-Yee, Tan Henry K K, Goh Boon-Cher, Putti Thomas C
Department of Paediatric Medicine, Kandang Kerbau Women's and Children's Hospital, Singapore.
Ann Acad Med Singap. 2006 Feb;35(2):104-7.
The development of secondary tumours as a result of radiation therapy is a rare but serious complication.
This is a case report of a 45-year-old Chinese male who developed postirradiation sarcoma of the sphenoid bone in less than 5 years after radiation therapy for Stage T3N1M0 nasopharyngeal carcinoma.
In the literature, the only case of postirradiation osteosarcoma of the sphenoid bone was after radiation therapy for craniopharyngioma. There was no previously reported case of postirradiation sarcoma of the sphenoid bone after radiation therapy for nasopharyngeal carcinoma.
This is the first case of postirradiation malignant fibrous histiocytoma of the sphenoid to be reported. Of about 3000 patients treated with radiotherapy for nasopharyngeal carcinoma over a 10-year period in Singapore, only 1 patient developed postirradiation tumour of the sphenoid bone.
放射治疗导致的继发性肿瘤是一种罕见但严重的并发症。
这是一例45岁中国男性的病例报告，该患者在接受T3N1M0期鼻咽癌放射治疗后不到5年发生了蝶骨放疗后肉瘤。
在文献中，蝶骨放疗后骨肉瘤的唯一病例是在颅咽管瘤放疗后。此前尚无鼻咽癌放疗后蝶骨放疗后肉瘤的报道病例。
这是首例报告的蝶骨放疗后恶性纤维组织细胞瘤。在新加坡10年期间接受鼻咽癌放疗的约3000例患者中，仅有1例发生了蝶骨放疗后肿瘤。
