Brat O, Ziv I, Klinger B, Avraham M, Laron Z
Endocrinology and Diabetes Research Unit, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Horm Res. 1997;47(2):45-8. doi: 10.1159/000185429.
Muscle force and endurance of four muscle groups (biceps, triceps, hamstrings and quadriceps) were measured by a computerized device in three groups: (A) 4 boys with isolated growth hormone deficiencies (IGHD) examined before at 10 and 24 months of hGH treatment; (B) 5 children (2 F, 3 M) with Laron syndrome were examined 3.5-4 years after initiation of insulin-like growth factor-I (IGF-I) treatment, and (C) comprised 8 untreated adults (5 F, 3 M) with Laron syndrome. For each patient, 2 matched controls, by age, sex, physical activity and height below the 50th percentile, were examined. GH- or IGF-I-deficient patients before treatment revealed reduced muscle force and endurance. GH treatment (0.6 U/kg/week) restored muscle force and endurance, progressively, mainly in the boys with puberty. Three to 4 years of IGF-I treatment (150 micrograms/kg/day) in patients with Laron syndrome proved to have a weaker effect than GH in restoring muscle force. The difference in effectiveness between hGH and IGF-I in restoring muscle force may be due to either the more marked muscle underdevelopment in Laron syndrome patients than in patients with IGHD or a difference in action potential between the two hormones.
使用计算机设备测量了三组人群中四个肌肉群（肱二头肌、肱三头肌、腘绳肌和股四头肌）的肌肉力量和耐力：（A）4名患有孤立性生长激素缺乏症（IGHD）的男孩，在生长激素（hGH）治疗10个月和24个月时接受检查；（B）5名患有拉伦综合征的儿童（2名女性，3名男性），在开始胰岛素样生长因子-I（IGF-I）治疗3.5 - 4年后接受检查；（C）包括8名未接受治疗的患有拉伦综合征的成年人（5名女性，3名男性）。对于每位患者，检查了2名年龄、性别、体力活动和身高处于第50百分位数以下相匹配的对照者。治疗前生长激素或胰岛素样生长因子-I缺乏的患者肌肉力量和耐力降低。生长激素治疗（0.6 U/kg/周）逐渐恢复了肌肉力量和耐力，主要是在青春期男孩中。对于患有拉伦综合征的患者，3至4年的胰岛素样生长因子-I治疗（150微克/千克/天）在恢复肌肉力量方面的效果被证明比生长激素弱。生长激素和胰岛素样生长因子-I在恢复肌肉力量方面有效性的差异可能是由于拉伦综合征患者的肌肉发育不全比孤立性生长激素缺乏症患者更明显，或者是由于这两种激素的动作电位不同。
