生长激素受体基因缺失（GHR-/-）小鼠的内分泌参数和表型。
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.
机构信息
The Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA.
出版信息
Endocr Rev. 2011 Jun;32(3):356-86. doi: 10.1210/er.2010-0009. Epub 2010 Dec 1.
Abstract
Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging. Some of the most notable discoveries are their extreme insulin sensitivity in the presence of obesity. Also, the animals have an extended lifespan, which has generated a large number of investigations into the roles of GH and IGF-I in the aging process. This review summarizes the many results derived from the GHR-/- mice. We have attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans.
摘要
生长激素受体（GHR）基因的破坏消除了 GH 诱导的细胞内信号转导，从而消除了其生物学作用。因此，GHR 基因敲除小鼠（GHR-/-）一直是并且是帮助定义 GH 生理学各种参数的有价值的工具。自 1995 年创建以来，我们实验室和其他实验室已经使用这种品系进行了许多研究，从生长到衰老。最值得注意的发现之一是它们在肥胖存在的情况下具有极高的胰岛素敏感性。此外，这些动物的寿命延长，这引发了大量关于 GH 和 IGF-I 在衰老过程中的作用的研究。本综述总结了 GHR-/-小鼠得出的许多结果。我们试图根据关于 GH 作用的当前知识来呈现这些发现，并在适用的情况下讨论这些小鼠与人类 GH 不敏感综合征的比较。
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