Sawazaki A, Nakamura N, Jyokaji H, Minami S, Nakamura S, Matsuda T
Department of Internal Medicine, Inami Municipal General Hospital, Toyama.
Intern Med. 1996 Dec;35(12):996-9. doi: 10.2169/internalmedicine.35.996.
A 35-year-old man with Guillain-Barré syndrome and ethylene diamine tetraacetic acid (EDTA)-dependent pseudothrombocytopenia associated with serologically-confirmed mumps is presented. A polyneuropathy developed 18 days after the onset of mumps, that improved with plasmapheresis. A decreased platelet count was observed 25 days after the onset of mumps attributed to platelet agglutination in blood anticoagulated with EDTA, and the agglutination was prevented by other anticoagulants. Guillain-Barré syndrome associated with mumps is rare and EDTA-dependent pseudothrombocytopenia following mumps has never been documented. This represents the first report of Guillain-Barré syndrome and EDTA-dependent pseudothrombocytopenia following mumps. Furthermore, our findings suggest activation of the humoral immune response as a potential pathogenesis.
本文报告了一名35岁男性，患有吉兰-巴雷综合征和与血清学确诊的腮腺炎相关的乙二胺四乙酸（EDTA）依赖性假性血小板减少症。腮腺炎发病18天后出现多发性神经病，经血浆置换后病情改善。腮腺炎发病25天后观察到血小板计数下降，这归因于用EDTA抗凝的血液中血小板凝集，而其他抗凝剂可防止凝集。腮腺炎相关的吉兰-巴雷综合征罕见，腮腺炎后EDTA依赖性假性血小板减少症从未有过记录。这是腮腺炎后吉兰-巴雷综合征和EDTA依赖性假性血小板减少症的首例报告。此外，我们的研究结果提示体液免疫反应激活可能是其发病机制。
