Kim Hee Jun, Moh In Ho, Yoo Hana, Son Seungyeon, Jung DA Hye, Lee Hun Gu, Han Dong Hee, Park Jae Hyun, Kim Hyeong Su, Kim Jung Han
Department of Internal Medicine, Hallym Medical Center, Hallym University College of Medicine, Seoul 150-950, Republic of Korea.
Oncol Lett. 2012 Jul;4(1):86-88. doi: 10.3892/ol.2012.675. Epub 2012 Apr 11.
Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon of EDTA-induced platelet aggregation at room temperature. This phenomenon consists of platelet clumping due to anti-platelet antibodies in blood anticoagulated with EDTA. It has been reported in patients with various diseases, including sepsis, multiple myeloma, acute myocardial infarction and breast cancer. Since unrecognized EDTA-PTCP may lead to inappropriate treatment, it should always be considered as a possible cause in patients with low platelet counts. This study identified a case of transient EDTA-PTCP in a patient with neuroendocrine carcinoma of the stomach. In the present study, a 50-year-old male presented with epigastric pain and a weight loss of 15 kg. The patient presented with EDTA-PTCP and was diagnosed with neuroendocrine carcinoma of the stomach. Following systemic chemotherapy, the tumor showed a marked regression and the EDTA-PTCP disappeared. The mechanism by which this occurred is not clear but an association of EDTA-PTCP with neuroendocrine carcinoma is strongly suggested.
乙二胺四乙酸依赖性假性血小板减少症（EDTA-PTCP）是一种在室温下由EDTA诱导血小板聚集的体外现象。这种现象是由于用EDTA抗凝的血液中存在抗血小板抗体导致血小板聚集。在包括败血症、多发性骨髓瘤、急性心肌梗死和乳腺癌在内的各种疾病患者中均有报道。由于未识别的EDTA-PTCP可能导致不适当的治疗，因此在血小板计数低的患者中应始终将其视为可能的病因。本研究报告了1例胃神经内分泌癌患者发生的短暂性EDTA-PTCP。在本研究中，一名50岁男性出现上腹部疼痛，体重减轻15千克。该患者出现EDTA-PTCP，并被诊断为胃神经内分泌癌。全身化疗后，肿瘤明显消退，EDTA-PTCP消失。其发生机制尚不清楚，但强烈提示EDTA-PTCP与神经内分泌癌有关。
