Hermann R, Ripamonti F, Romanò G, Restelli E, Ferrari P, Goldstein B P, Berti M, Ciabatti R
Lepetit Research Center, Gerenzano (Varese), Italy.
J Antibiot (Tokyo). 1996 Dec;49(12):1236-48. doi: 10.7164/antibiotics.49.1236.
Starting from the antibiotic A-40926 and the aglycone of A-40926 a series of compounds were prepared by modifying the free functionalities. Their antimicrobial activity was determined, particularly against Neisseria gonorrhoeae, against which A-40926, unlike other natural glycopeptides, is active. Improved in vivo activity was displayed by the monomethyl ester of A-40926 esterified at the carboxyl group of the N-acylamino-glucuronyl moiety.
从抗生素A - 40926及其苷元出发，通过修饰游离官能团制备了一系列化合物。测定了它们的抗菌活性，特别是针对淋病奈瑟菌的活性，与其他天然糖肽不同，A - 40926对其具有活性。在N - 酰基氨基葡萄糖醛酸部分的羧基处酯化的A - 40926单甲酯表现出改善的体内活性。
