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Synthesis and biological activity of some esters of the N-acetylglucosaminyl aglycone and of the aglycone of teicoplanin.

作者信息

Malabarba A, Trani A, Ferrari P, Pallanza R, Cavalleri B

机构信息

Lepetit Research Center, Gerenzano (VA), Italy.

出版信息

J Antibiot (Tokyo). 1987 Nov;40(11):1572-87. doi: 10.7164/antibiotics.40.1572.

DOI:10.7164/antibiotics.40.1572
PMID:2961722
Abstract

A series of ester derivatives of teicoplanin-N-acetylglucosaminyl aglycone (T-A3-2) and deglucoteicoplanin was prepared starting from teicoplanin and from the corresponding deglycosylation compounds. The modification of the ionic and lipophilic character of the parent antibiotic strongly influences the spectrum of antibacterial activity in vitro.

摘要

相似文献

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