Dabadghao P, Bhatia E, Bhatia V, Jayaraj K, Colman P G
Department of Endocrinology, Sanjay Gandhi Postgraduate, Institute of Medical Sciences, Lucknow, India.
Diabetes Res Clin Pract. 1996 Oct;34(2):73-8. doi: 10.1016/s0168-8227(96)01336-8.
The etiology of malnutrition-related diabetes mellitus (MRDM)--protein-deficient pancreatic diabetes (PDPD) and fibro-calculous pancreatic diabetes (FCPD)-is unclear. We studied the role of autoimmunity against pancreatic islet cells in the etiology of these two subtypes of MRDM by measuring islet-cell antibodies (ICA) in 23 patients with PDPD, 25 with FCPD and 62 with Type 1 diabetes. Three patients (13%) with PDPD had detectable ICA. Including a patient with a high titre of ICA (> 80 JDF units). The frequency of ICA in patients with PDPD was significantly lower than subjects with Type 1 diabetes (22/62, 35%; P < 0.05). Among patients studied at onset. ICA prevalence was lower in the PDPD patients (1/7, 14%) compared to subjects with Type 1 diabetes (8/20, 40%). No patient of FCPD had detectable ICA (P < 0.001 vs. Type 1 diabetes subjects). We conclude that autoimmunity may play a role in the etiology of some patients with the PDPD subtype of MRDM. However, FCPD is unlikely to have an autoimmune etiology.
营养不良相关性糖尿病（MRDM）——蛋白质缺乏性胰腺糖尿病（PDPD）和纤维钙化性胰腺糖尿病（FCPD）的病因尚不清楚。我们通过检测23例PDPD患者、25例FCPD患者和62例1型糖尿病患者的胰岛细胞抗体（ICA），研究了针对胰岛细胞的自身免疫在这两种MRDM亚型病因中的作用。3例（13%）PDPD患者可检测到ICA，包括1例高滴度ICA（>80 JDF单位）的患者。PDPD患者中ICA的频率显著低于1型糖尿病患者（22/62，35%；P<0.05）。在发病时研究的患者中，PDPD患者的ICA患病率（1/7，14%）低于1型糖尿病患者（8/20，40%）。FCPD患者均未检测到ICA（与1型糖尿病患者相比，P<0.001）。我们得出结论，自身免疫可能在部分MRDM的PDPD亚型患者的病因中起作用。然而，FCPD不太可能有自身免疫病因。
