印度南部所见糖尿病患者中针对胰岛细胞抗原的抗体，特别提及纤维钙化性胰腺糖尿病。

Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes.

作者信息

Mohan V, Deepa R, Bhatia E, Singh A K, Hitman G A, Zimmet P Z, MacKay I R

机构信息

M.V. Diabetes Specialites Centre, and Madras Diabetes Research Foundation, Gopalapuram, Chennai, India.

出版信息

Diabet Med. 1998 Feb;15(2):156-9. doi: 10.1002/(SICI)1096-9136(199802)15:2<156::AID-DIA533>3.0.CO;2-E.

DOI:10.1002/(SICI)1096-9136(199802)15:2<156::AID-DIA533>3.0.CO;2-E

PMID:9507918

Abstract

Fibrocalculous pancreatic diabetes (FCPD) is a type of diabetes secondary to tropical chronic non-alcoholic pancreatitis. Little is known about the aetiopathogenesis of FCPD. We studied glutamic acid decarboxylase antibodies (GAD-Ab) and islet cell antibodies (ICA) in patients with FCPD and compared the results with Type 1 (insulin dependent) diabetes mellitus, Type 2 (non-insulin-dependent) diabetes mellitus and non-diabetic subjects in Southern India. The prevalence of GAD-Ab was 7.0% (95% Confidence Interval (CI) 1.9-17.2) in FCPD, 47.5% (CI 31.4-64.0) in Type 1 (p < 0.001 compared to FCPD), 5.6% (CI 1.5-13.9) in Type 2 (non-significant (NS) compared to FCPD) and 0% in controls. The prevalence of ICA was 6.3% (CI 1.2-17.4) in FCPD, 53.8% (CI 37.1-70.0) in Type 1 (p < 0.001 compared to FCPD), 9.9% (CI 4.0-19.4) in Type 2 (NS compared to FCPD) and 4.7% (CI 0.4-16.1) in controls. The data suggest that in FCPD, the frequency of auto-antibodies is low and its aetiology is probably not linked to autoimmunity in the majority of the patients.

摘要

纤维钙化性胰腺糖尿病（FCPD）是一种继发于热带慢性非酒精性胰腺炎的糖尿病。关于FCPD的病因发病机制知之甚少。我们研究了FCPD患者的谷氨酸脱羧酶抗体（GAD-Ab）和胰岛细胞抗体（ICA），并将结果与印度南部的1型（胰岛素依赖型）糖尿病、2型（非胰岛素依赖型）糖尿病患者及非糖尿病受试者进行了比较。FCPD患者中GAD-Ab的患病率为7.0%（95%置信区间（CI）1.9 - 17.2），1型糖尿病患者中为47.5%（CI 31.4 - 64.0）（与FCPD相比，p < 0.001），2型糖尿病患者中为5.6%（与FCPD相比无显著差异（NS）），对照组中为0%。FCPD患者中ICA的患病率为6.3%（CI 1.2 - 17.4），1型糖尿病患者中为53.8%（CI 37.1 - 70.0）（与FCPD相比，p < 0.001），2型糖尿病患者中为9.9%（与FCPD相比无显著差异），对照组中为4.7%（CI 0.4 - 16.1）。数据表明，在FCPD中，自身抗体的频率较低，并且在大多数患者中其病因可能与自身免疫无关。