Montgomery S A
Imperial College School of Medicine at St Mary's, London, UK.
Int Clin Psychopharmacol. 1996 Dec;11 Suppl 5:23-9. doi: 10.1097/00004850-199612005-00004.
Obsessive-compulsive disorder (OCD) is a chronic debilitating condition that requires long-term treatment. The selective serotonin reuptake inhibitors (SSRIs) appear to be associated with similar levels of efficacy to clomipramine in short-term treatment, but to have significant tolerability advantages. The results of the long-term controlled studies on clomipramine, fluvoxamine, fluoxetine and sertraline are reviewed. They demonstrate a significantly better outcome for anti-obsessional drugs than placebo. The absence of adequate long-term controlled studies on pharmacotherapy strengthen the grounds for recommending pharmacotherapy as the optimal approach for long-term treatment of OCD. The SSRIs would appear to be the treatment of choice in OCD in view of their tolerability and safety advantages compared with clomipramine.
强迫症（OCD）是一种慢性致残性疾病，需要长期治疗。选择性5-羟色胺再摄取抑制剂（SSRIs）在短期治疗中似乎与氯米帕明具有相似的疗效水平，但具有显著的耐受性优势。本文综述了关于氯米帕明、氟伏沙明、氟西汀和舍曲林的长期对照研究结果。这些结果表明，抗强迫药物的疗效明显优于安慰剂。由于缺乏足够的关于药物治疗的长期对照研究，因此更有理由推荐药物治疗作为强迫症长期治疗的最佳方法。鉴于与氯米帕明相比，SSRIs具有耐受性和安全性优势，它们似乎是强迫症治疗的首选药物。
