Ravizza L, Barzega G, Bellino S, Bogetto F, Maina G
Department of Psychiatry, University of Turin, Italy.
Psychopharmacol Bull. 1996;32(1):167-73.
A 2-year, open-label followup was performed on 130 obsessive-compulsive patients who were responders to a previous 6-month treatment with clomipramine (150 mg/day), fluoxetine (40 mg/day), or fluvoxamine (300 mg/day). Continuation treatment with the same daily dose was compared to continuation with half doses or to discontinuation of pharmacotherapy. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Clinical Global Impressions (CGI) scale were used every 3 months, or whenever a worsening of symptoms was experienced. Maintenance treatments were found significantly superior to discontinuation in preventing relapses, and no differences in efficacy were found between full and half doses. A comparison of the three subgroups of patients who were withdrawn from drug therapy failed to demonstrate any statistical difference.
对130名强迫症患者进行了为期2年的开放标签随访，这些患者对之前为期6个月的氯米帕明（150毫克/天）、氟西汀（40毫克/天）或氟伏沙明（300毫克/天）治疗有反应。将相同日剂量的持续治疗与半剂量持续治疗或停止药物治疗进行比较。每3个月或在症状恶化时使用耶鲁-布朗强迫症量表（Y-BOCS）和临床总体印象（CGI）量表。在预防复发方面发现维持治疗明显优于停药，全剂量和半剂量之间未发现疗效差异。对停止药物治疗的三个亚组患者进行比较，未显示出任何统计学差异。
