Wagenmann M, Baroody F M, Cheng C C, Kagey-Sobotka A, Lichtenstein L M, Naclerio R M
Department of Medicine (Division of Clinical Immunology), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Am J Respir Crit Care Med. 1997 Feb;155(2):426-31. doi: 10.1164/ajrccm.155.2.9032173.
Studying the inflammatory response that follows the early response to nasal challenge with antigen provides a better understanding of allergic rhinitis than just studying the immediate (early) response. Nine allergic volunteers were challenged unilaterally with antigen-containing discs, and bilateral changes in physiologic responses as well as in the concentration of histamine in nasal secretions were measured for 11 h. We found significant immediate increases in symptoms, sneezes, ipsilateral nasal airway resistance, and ipsilateral histamine in the early phase response. Two-thirds of the allergen-challenged volunteers showed increases in physiologic parameters or histamine in the hours after allergen challenge. The pooled data of all subjects exhibited significant increases in bilateral nasal airway resistance and in ipsilateral and contralateral histamine, hours after unilateral provocation. These responses differed significantly from control subjects. In another group of 11 volunteers challenged ipsilaterally with antigen, the number of basophils increased both on the side of challenge and on the contralateral side. The magnitude of the increase on the ipsilateral side correlated with the increase on the contralateral side (r(s) = 0.72). The basophils are the most likely source of the contralateral increase in histamine as they are on the ipsilateral side. Although the mechanisms underlying this contralateral increase in basophils and histamine are not known, we speculate that delayed, neurogenic responses play a contributory role.
研究抗原鼻激发早期反应后的炎症反应，比仅研究即时（早期）反应能更好地理解变应性鼻炎。9名变应性志愿者单侧接受含抗原的圆片激发，测量11小时内生理反应以及鼻分泌物中组胺浓度的双侧变化。我们发现在早期反应中，症状、喷嚏、同侧鼻气道阻力和同侧组胺均有显著的即时增加。三分之二接受变应原激发的志愿者在变应原激发后的数小时内生理参数或组胺增加。所有受试者的汇总数据显示，单侧激发数小时后，双侧鼻气道阻力以及同侧和对侧组胺均显著增加。这些反应与对照受试者有显著差异。在另一组11名志愿者中，单侧接受抗原激发，激发侧和对侧的嗜碱性粒细胞数量均增加。同侧增加的幅度与对侧增加的幅度相关（斯皮尔曼等级相关系数r(s)=0.72）。嗜碱性粒细胞很可能是对侧组胺增加的来源，因为它们位于同侧。虽然这种对侧嗜碱性粒细胞和组胺增加的潜在机制尚不清楚，但我们推测延迟的神经源性反应起了一定作用。
