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猪圆环病毒DNA复制起点的定位与特性分析

Mapping and characterization of the origin of DNA replication of porcine circovirus.

作者信息

Mankertz A, Persson F, Mankertz J, Blaess G, Buhk H J

机构信息

Fachbereich Gentechnik und Genetik, Robert Koch-Institut, Berlin, Germany.

出版信息

J Virol. 1997 Mar;71(3):2562-6. doi: 10.1128/JVI.71.3.2562-2566.1997.

DOI:10.1128/JVI.71.3.2562-2566.1997
PMID:9032401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC191374/
Abstract

The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep proteins.

摘要

猪圆环病毒（PCV）的DNA复制起点被定位到一个111碱基对的片段上。在一个发夹结构之上，发现了一个与其他病毒的九核苷酸（TAGTATTAC）同源的九核苷酸。该元件的突变会使复制停止。PCV可能与一个以单链环状DNA基因组、滚环复制及其复制蛋白同源性为特征的病毒科有关。

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本文引用的文献

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A DNA structure is required for geminivirus replication origin function.双生病毒复制起点功能需要DNA结构。
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