自再生骨植入物：rhBMP-2、I型脱端肽胶原蛋白和多孔羟基磷灰石组合肌内植入后的异位骨诱导
Self-regenerating bone implant: ectopic osteoinduction following intramuscular implantation of a combination of rhBMP-2, atelopeptide type I collagen and porous hydroxyapatite.
作者信息
Kusumoto K, Bessho K, Fujimura K, Konishi Y, Ogawa Y, Iizuka T
机构信息
Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan.
出版信息
J Craniomaxillofac Surg. 1996 Dec;24(6):360-5. doi: 10.1016/s1010-5182(96)80037-0.
A combination of recombinant human bone morphogenetic protein-2 (rhBMP-2), atelopeptide Type I collagen (CL) as a carrier and porous hydroxyapatite (pHAP) was implanted in a calf muscle pouch of the rat. Three rhBMP-2-implanted groups (2, 10 and 50 micrograms; each n = 5) and the control group (n = 5), in which only CL and pHAP were implanted, were established. Three weeks later, the implants were examined.
将重组人骨形态发生蛋白-2（rhBMP-2）、作为载体的I型脱端肽胶原蛋白（CL）和多孔羟基磷灰石（pHAP）的组合植入大鼠的小腿肌肉袋中。设立了三个植入rhBMP-2的组（2、10和50微克；每组n = 5）和对照组（n = 5），对照组仅植入CL和pHAP。三周后，对植入物进行检查。
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