King A, Burrows T, Loke Y W
Department of Pathology, University of Cambridge, UK.
Nat Immun. 1996;15(1):41-52.
The human uterine mucosa is infiltrated by large numbers of CD56+ natural killer (NK) cells which are particularly abundant around the time of implantation and during early pregnancy. These NK cells have the phenotype CD56bright CD16-mCD3- and the characteristic morphology of large granular lymphocytes. The NK cells are in close association with the trophoblast cells which invade into the uterus. The expression of HLA class I antigens, HLA-G and HLA-C, by these trophoblast cells raises the possibility that maternal NK cells can recognise and respond to the fetal trophoblast cells. Thus, the maternal-fetal interaction, and hence reproductive success, may depend on an NK allorecognition system.
人类子宫黏膜中有大量CD56+自然杀伤（NK）细胞浸润，这些细胞在着床期和妊娠早期尤为丰富。这些NK细胞具有CD56bright CD16-mCD3-的表型以及大颗粒淋巴细胞的特征形态。NK细胞与侵入子宫的滋养层细胞紧密相连。这些滋养层细胞表达的I类人类白细胞抗原（HLA）、HLA-G和HLA-C增加了母体NK细胞识别并对胎儿滋养层细胞作出反应的可能性。因此，母胎相互作用乃至生殖成功可能依赖于一种NK同种异体识别系统。
