伽玛刀放射外科治疗听神经瘤：低辐射剂量的效果及功能预后

Gamma Knife radiosurgery for acoustic schwannoma: effects of low radiation dose and functional prognosis.

作者信息

Hirato M, Inoue H, Zama A, Ohye C, Shibazaki T, Andou Y

机构信息

Department of Neurosurgery, Gunma University School of Medicine, Hidaka Hospital, Maebashi, Japan.

出版信息

Stereotact Funct Neurosurg. 1996;66 Suppl 1:134-41. doi: 10.1159/000099803.

DOI:10.1159/000099803

PMID:9032854

Abstract

The effects of relatively low dose Gamma Knife irradiation on acoustic schwannoma were evaluated in 29 patients followed over 2 years after treatment. The mean dose delivered to the tumor periphery was 12.1 Gy. Lowering of the magnetic resonance signal intensity in the tumor center appeared in 69% and signs of tumor shrinkage appeared in 59% of cases. The cyst in the tumor enlarged in 3 cases, and 2 cases developed hydrocephalus. The percentage of pure-tone hearing preservation was 82% at 3 months, 73% at 6 months, 68% at 12 months. 64% at 18 months and 59% at 24 months in 22 out of 29 cases. Relatively low dose Gamma Knife radiosurgery was effective in suppressing tumor growth, with preservation of hearing.

摘要

对29例接受治疗后随访2年以上的听神经瘤患者，评估了相对低剂量伽玛刀照射的效果。肿瘤周边的平均照射剂量为12.1 Gy。69%的病例肿瘤中心磁共振信号强度降低，59%的病例出现肿瘤缩小迹象。3例肿瘤内囊肿增大，2例发生脑积水。29例中的22例，纯音听力保留率在3个月时为82%，6个月时为73%，12个月时为68%，18个月时为64%，24个月时为59%。相对低剂量伽玛刀放射外科手术在抑制肿瘤生长并保留听力方面有效。