Luey K Y, Kam K M
Department of Health, Sai Ying Pun Polyclinic, Hong Kong.
Vaccine. 1996 Dec;14(17-18):1573-80. doi: 10.1016/s0264-410x(96)00156-9.
Two hundred and four isolates of Streptococcus pneumoniae obtained from children and adults in Hong Kong between January 1993 and May 1995 were analysed for serotype and serogroup (SGT) distribution and antibiotic resistance. The predominant serogroups and serotypes (SGTs) were 23, 19, 6 and 3 which accounted for 19.6%, 16.7%, 15.2% and 7.8% of all isolates, respectively. Altogether, 83.8% of all isolates were related to the current 23-valent pneumococcal vaccine. Sixty-six (32.4%) isolates demonstrated multiple antibiotic resistance, defined as resistance to three or more different antibiotics. SGTs 19, 23 and 6 occurred significantly more frequently in this group than in the groups with less antibiotic resistance (97% vs 30%; P < 0.001). Isolates shown to be resistant to all five antibiotics tested (penicillin, chloramphenicol, ceftriaxone, macrolides and tetracycline) were found only in serogroups 6, 19 and 23. The 23-valent vaccine should cover 84.4% (152/180) of SGTs with one or more antibiotic resistance in all age groups, while the proposed 9-valent global pneumococcal conjugate vaccine should cover 85.0% (34/40) of such SGTs in children.
对1993年1月至1995年5月间从香港儿童和成人中分离出的204株肺炎链球菌进行了血清型和血清群（SGT）分布及抗生素耐药性分析。主要的血清群和血清型（SGTs）分别为23、19、6和3型，分别占所有分离株的19.6%、16.7%、15.2%和7.8%。总体而言，所有分离株中有83.8%与目前的23价肺炎球菌疫苗相关。66株（32.4%）分离株表现出多重抗生素耐药性，定义为对三种或三种以上不同抗生素耐药。血清型19、23和6在该组中出现的频率明显高于抗生素耐药性较低的组（97%对30%；P<0.001）。仅在血清群6、19和23中发现对所有五种测试抗生素（青霉素、氯霉素、头孢曲松、大环内酯类和四环素）均耐药的分离株。23价疫苗应覆盖所有年龄组中一种或多种抗生素耐药的SGTs的84.4%（152/180），而提议的9价全球肺炎球菌结合疫苗应覆盖儿童中此类SGTs的85.0%（34/40）。
