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[光化学疗法治疗早期(Tis、T1)声带癌]

[Photochemotherapy in the treatment of carcinoma of the vocal cords of early stage (Tis, T1)].

作者信息

Delbove H, de Corbière S, Fugain C, Freche C, Chabolle F

机构信息

Service d'ORL et de Chirurgie Cervico-Maxillo-Faciale, Hôpital Foch, Suresnes.

出版信息

Ann Otolaryngol Chir Cervicofac. 1996;113(3):155-61.

PMID:9033679
Abstract

Photodynamic Therapy (PDT) is a treatment which can prove interesting in head and neck oncology for small squamous cell carcinomas. We studied 33 patients with vocal cord squamous cell carcinoma at an early stage who have been treated by Photodynamic Therapy from 1986 to 1992. We used a Dye Laser Aurora which produces light with a wavelength of 630 nm. The intervention was done under general anesthesia, 72 hours after the injection of hematoporphyrin derivative. The mean and the maximum follow-up was respectively 66 and 93 months. The local control after an exclusive PDT was 73% at 3 years, 5 years, 7 years. If this method fails, a conventional treatment may be used.

摘要

光动力疗法(PDT)是一种在头颈部肿瘤学中对小的鳞状细胞癌可能有效的治疗方法。我们研究了1986年至1992年间接受光动力疗法治疗的33例早期声带鳞状细胞癌患者。我们使用了一台能产生波长为630纳米光的染料激光极光仪。干预在全身麻醉下进行,在注射血卟啉衍生物72小时后进行。平均随访时间和最长随访时间分别为66个月和93个月。单纯光动力疗法后的局部控制率在3年、5年、7年时分别为73%。如果这种方法失败,可以采用传统治疗方法。

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