Zerbib F, Bruley des Varannes S, Rozé D C, Galmiche J P
Centre de Recherche en Nutrition Humaine, CRI INSERM (4U 008 B), Nantes.
Gastroenterol Clin Biol. 1996;20(12):1078-83.
The aim of this study was to determine the feasibility and tolerance of simultaneous assessment of the proximal gastric and lower esophageal sphincter tones in healthy humans, in fasting and fed conditions.
Esophageal motility and lower esophageal sphincter tone were measured on two separate days in 7 healthy subjects. During one of these sessions, proximal gastric tone was simultaneously assessed with a balloon placed in the proximal stomach and connected to an electronic barostat. Motility was monitored 1 hour before and 4 hours after a liquid fat meal (400 mL/600 kcal). In four other healthy subjects, simultaneous assessment of proximal gastric and lower esophageal sphincter tones was performed after, suggestion of a 200 mL/200 kcal liquid meal.
Simultaneous use of gastric barostat and esophageal motility device was well tolerated in 10/11 healthy subjects. The presence of the barostat balloon did not significantly affect basal lower esophageal sphincter tone and the rate of transient lower esophageal sphincter relaxations. The important fall of lower esophageal sphincter basal tone after ingestion of the 400 mL/600 kcal meal did not allow to detect a post-prandial increase of transient lower esophageal sphincter; relaxations. After ingestion of the 200 mL/200 kcal meal, the incidence of transient lower esophageal sphincter relaxations increased (p < 0.02 vs. fasting). Maximal gastric relaxation was reached 15 min after meal, and appeared shorter (112 +/- 17 min vs. 167 +/- 24 min) and more pronounced (292 +/- 26 mL vs. 190 +/- 51 mL) than after the 400 mL meal, but differences were not statistically significant.
Simultaneous assessment of proximal gastric and lower esophageal sphincter tone is feasible, after oval ingestion of a meal. Since the 400 mL meal induces in important inhibition of lower esophageal sphincter basal tone, the 200 mL meal seems more adequate for assessment of the transient lower esophageal sphincter relaxations.
本研究旨在确定在空腹和进食状态下，对健康人同时评估近端胃和食管下括约肌张力的可行性和耐受性。
在7名健康受试者的两个不同日子测量食管动力和食管下括约肌张力。在其中一次测量期间，通过放置在近端胃并连接到电子恒压器的气球同时评估近端胃张力。在液体脂肪餐（400 mL/600 kcal）前1小时和后4小时监测动力。在另外4名健康受试者中，在给予200 mL/200 kcal液体餐后进行近端胃和食管下括约肌张力的同时评估。
11名健康受试者中有10名对同时使用胃恒压器和食管动力装置耐受性良好。恒压器气球的存在并未显著影响基础食管下括约肌张力和食管下括约肌短暂松弛的发生率。摄入400 mL/600 kcal餐后食管下括约肌基础张力的显著下降使得无法检测到餐后食管下括约肌短暂松弛的增加。摄入200 mL/200 kcal餐后，食管下括约肌短暂松弛的发生率增加（与空腹相比，p < 0.02）。最大胃松弛在餐后15分钟达到，且与400 mL餐相比，出现的时间更短（112±17分钟对167±24分钟）且更明显（292±26 mL对190±51 mL），但差异无统计学意义。
在进食一顿饭后，同时评估近端胃和食管下括约肌张力是可行的。由于400 mL餐会导致食管下括约肌基础张力的重要抑制，200 mL餐似乎更适合评估食管下括约肌的短暂松弛。
