Ahrén B, Larsson H
Department of Medicine, Lund University, Malmö University Hospital, Sweden.
Acta Diabetol. 1996 Dec;33(4):295-7. doi: 10.1007/BF00571568.
Neuropeptide Y (NPY) has been shown to be associated with insulin resistance, since central administration of the peptide induces muscular insulin resistance. NPY also occurs in pancreatic nerves and inhibits insulin secretion. In this study, we examined the plasma NPY levels in 10 women, aged 57-59 years, with impaired glucose tolerance (IGT), which is often accompanied by a combination of reduced insulin sensitivity and impaired insulin secretion. They were 145 +/- 4.1 pmol/l compared with 143 +/- 4.3 pmol/l in 10 age-matched women with normal glucose tolerance (NGT) (NS). Furthermore, the plasma NPY did not correlate with fasting glucose or insulin levels, the 2-h glucose value after a 75 g oral glucose challenge or insulin sensitivity as determined by the euglycemic, hyperinsulinemic clamp technique. This suggests that plasma NPY is not altered in IGT.
神经肽Y（NPY）已被证明与胰岛素抵抗有关，因为向中枢给予该肽会诱导肌肉胰岛素抵抗。NPY也存在于胰腺神经中，并抑制胰岛素分泌。在本研究中，我们检测了10名年龄在57 - 59岁之间、糖耐量受损（IGT）的女性的血浆NPY水平，糖耐量受损常伴有胰岛素敏感性降低和胰岛素分泌受损。她们的血浆NPY水平为145±4.1 pmol/l，而10名年龄匹配的糖耐量正常（NGT）女性的血浆NPY水平为143±4.3 pmol/l（无显著性差异）。此外，血浆NPY与空腹血糖或胰岛素水平、75 g口服葡萄糖耐量试验后的2小时血糖值或通过正常血糖高胰岛素钳夹技术测定的胰岛素敏感性均无相关性。这表明IGT患者的血浆NPY没有改变。
