Edvinsson L, Ekman R, Thulin T
Department of Internal Medicine, Lund University, Sweden.
Regul Pept. 1991 Feb 26;32(3):279-87. doi: 10.1016/0167-0115(91)90021-8.
Circulating levels of neuropeptide Y (NPY)-like immunoreactivity (-LI), adrenaline and noradrenaline (NA) were analysed in 17 patients admitted to the emergency ward due to severe hypertension; blood pressure mean 204/127 mmHg. The levels of NPY-LI and NA were significantly higher (P less than 0.001) in the hypertensives as compared to a normotensive control group. HPLC analysis revealed that the plasma contained besides NPY-LI also several NPY-LI fragments of low hydrophobicity. Following 2 to 3 weeks treatment the blood pressure had decreased to a mean of 150/89 mmHg. However, circulating levels of NPY-LI (P less than 0.001) and NA (P less than 0.01) were still significantly higher than in controls in spite of the marked reduction in blood pressure. Simultaneous measurements of adrenaline did not reveal any significant changes and these values did not differ compared with those in the normotensive subjects. The findings suggest that peripheral markers of the sympathetic system (NPY-LI and NA) in severe hypertension is not directly related to the blood pressure level.
对17名因严重高血压入住急诊病房的患者（平均血压204/127 mmHg）的神经肽Y（NPY）样免疫反应性（-LI）、肾上腺素和去甲肾上腺素（NA）的循环水平进行了分析。与正常血压对照组相比，高血压患者的NPY-LI和NA水平显著更高（P<0.001）。高效液相色谱分析显示，血浆中除了NPY-LI外，还含有几种低疏水性的NPY-LI片段。经过2至3周的治疗后，血压降至平均150/89 mmHg。然而，尽管血压显著降低，但NPY-LI（P<0.001）和NA（P<0.01）的循环水平仍显著高于对照组。同时测量肾上腺素未发现任何显著变化，这些值与正常血压受试者的值无差异。研究结果表明，严重高血压患者交感神经系统的外周标志物（NPY-LI和NA）与血压水平没有直接关系。
