Hwu H G, Wu Y C, Lee S F, Yeh L L, Gwo S C, Hsu H C, Chang C J, Chen W J
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei.
Am J Med Genet. 1997 Feb 21;74(1):1-6.
Positive and negative symptom (NGS) dimensions were examined for their concordance in 46 coaffected schizophrenic sib-pairs. Results showed that the symptom dimensions of negative symptoms (NGS), delusion-hallucination (DHS), and thought disorganization (TDS) could be formulated. Discrete genetic endowment of these three symptom dimensions was not found as shown by the low concordance in sib pair analysis (kappa = 0.20-0.30). Thirty-seven pairs (80.4%) and 21 pairs (45.7%) had liability, defined by the presence of NGS in any one member of the coaffected sib-pairs, of NGS of "any degree", and of "severe degree" in 46 sib-pairs, respectively. Both groups had high prevalence (59.1-81.0%) of positive symptoms. Another 9 (19.6%) and 25 (54.3%) pairs had no liability of NGS of "any degree" or of "severe degree" out of 46 sib-pairs, respectively. These two groups had high concordance (kappa = 0.45-1.00) of TDS or DHS between coaffected sib-pairs. Based on the results, it is hypothesized that schizophrenia, as defined by DSM-III-R, may consist of two subtypes: one has liability of NGS and a high prevalence of positive symptoms, while the other has only positive symptoms.
对46对均患精神分裂症的同胞对进行了阳性和阴性症状（NGS）维度的一致性检查。结果显示，可以制定阴性症状（NGS）、妄想-幻觉（DHS）和思维紊乱（TDS）的症状维度。同胞对分析中的低一致性（kappa = 0.20 - 0.30）表明未发现这三个症状维度的离散遗传禀赋。在46对同胞对中，分别有37对（80.4%）和21对（45.7%）存在易感性，易感性定义为在均患精神分裂症的同胞对的任何一方中存在“任何程度”的NGS以及“严重程度”的NGS。两组的阳性症状患病率均较高（59.1 - 81.0%）。在46对同胞对中，另外分别有9对（19.6%）和25对（54.3%）不存在“任何程度”或“严重程度”的NGS易感性。这两组在均患精神分裂症的同胞对之间的TDS或DHS一致性较高（kappa = 0.45 - 1.00）。基于这些结果，推测DSM - III - R所定义的精神分裂症可能由两种亚型组成：一种具有NGS易感性且阳性症状患病率较高，而另一种仅具有阳性症状。
