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Hb S/Hb Lepore with mild sickling symptoms: a hemoglobin variant with mostly delta-chain sequences ameliorates sickle-cell disease.

作者信息

Fairbanks V F, McCormick D J, Kubik K S, Rezuke W N, Black D, Ochaney M S, Schwartz D

机构信息

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

出版信息

Am J Hematol. 1997 Feb;54(2):164-5. doi: 10.1002/(sici)1096-8652(199702)54:2<164::aid-ajh12>3.0.co;2-f.

DOI:10.1002/(sici)1096-8652(199702)54:2<164::aid-ajh12>3.0.co;2-f
PMID:9034293
Abstract

Three cases are reported of Hb S/Hb Lepore combination with very mild sickling manifestations. The presence of a nonalpha-chain variant with a high proportion of delta chain sequences, including 22 ala, appears to ameliorate sickle-cell disease. Efforts to increase the proportion of Hb A2 may be beneficial in sickle-cell disease.

摘要

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