Nichol M B, Margolies J E, Gill M A
Department of Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles 90033, USA.
Ann Pharmacother. 1997 Feb;31(2):154-9. doi: 10.1177/106002809703100203.
To investigate factors associated with treatment approaches to hypertension, a major risk factor for coronary heart and cerebrovascular disease and significant healthcare problem in the US. The study reports on three cross-sectional national surveys of patient-physician encounters.
Visits were selected for adults with hypertension diagnoses from the National Ambulatory Medical Care Surveys, which represent office encounters during a given year. Years of observation included 1989, 1990, and 1991.
Multiple variable logistic regression was used to identify predisposing need, enabling, and health utilization characteristics associated with whether the visit resulted in a prescription of an antihypertensive. Additionally, the association of these visits with combination therapy is determined.
For each of the 3 years, 69-75% of the encounters were associated with a prescription for drugs to treat hypertension. Prescribing is consistent with current literature demonstrating decreasing reliance on diuretics and beta-blockers, and increasing reliance on calcium antagonists. Combination therapy decreased as a percentage of prescriptions in 1990 and 1991. Variables associated with receiving an antihypertensive prescription included predisposing characteristics (patient age > 65 y), need characteristics (diagnosis of congestive hear failure [CHF]), and health utilization characteristics (physician specialty, previous diagnosis of hypertension). The most significant variables associated with combination therapy were predisposing characteristics (patient age > 65 y), need (CHF diagnosis, diagnosis of hypertension with end organ involvement), and health utilization characteristics (physician specialty).
These national estimates reinforce previous regional data regarding the categories of hypertension medications used. Patient visits involving multiple diagnoses, cardiologists, or patients older than 65 years, are more likely to generate prescriptions for combination antihypertensive therapy.
研究与高血压治疗方法相关的因素,高血压是冠心病和脑血管疾病的主要危险因素,也是美国一个重大的医疗保健问题。该研究报告了三项关于医患诊疗情况的全国性横断面调查。
从国家门诊医疗保健调查中选取被诊断为高血压的成年患者的就诊情况,这些调查代表了特定年份的门诊诊疗情况。观察年份包括1989年、1990年和1991年。
采用多变量逻辑回归来确定与就诊是否开具抗高血压药物处方相关的易患因素、促成因素和医疗利用特征。此外,还确定了这些就诊与联合治疗之间的关联。
在这三年中的每一年,69% - 75%的就诊都与开具治疗高血压的药物处方有关。处方情况与当前文献一致,表明对利尿剂和β受体阻滞剂的依赖在减少,而对钙拮抗剂的依赖在增加。1990年和1991年,联合治疗在处方中所占的比例有所下降。与开具抗高血压药物处方相关的变量包括易患因素(患者年龄>65岁)、需求因素(充血性心力衰竭[CHF]诊断)和医疗利用特征(医生专业、既往高血压诊断)。与联合治疗最相关的变量是易患因素(患者年龄>65岁)、需求因素(CHF诊断、伴有终末器官受累的高血压诊断)和医疗利用特征(医生专业)。
这些全国性估计结果强化了先前关于高血压用药类别的区域数据。涉及多种诊断、心脏病专家或65岁以上患者的就诊更有可能开具联合抗高血压治疗的处方。