White C M, Gailey R A, Levin G M, Smith T
Drug Information Center, Hartford Hospital, CT 06102, USA.
Ann Pharmacother. 1997 Feb;31(2):178-80. doi: 10.1177/106002809703100209.
To report a case of venlafaxine overdose.
A 40-year-old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt. After the ingestion of 26 venlafaxine 50-mg tablets, the patient experienced a witnessed generalized seizure. She was admitted to the medical intensive care unit, venlafaxine was discontinued, and no further sequelae were seen.
To our knowledge, this is the first reported case of venlafaxine overdose that resulted in a generalized seizure. Based on nonoverdose pharmacokinetics and pharmacodynamics of venlafaxine and the potential risks of available interventions, no emergent therapy was instituted.
The venlafaxine overdose in our patient resulted in a single episode of generalized seizure but elicited no further sequelae.
报告一例文拉法辛过量服用病例。
一名40岁患有重度抑郁症的女性明显试图自杀而过量服用了文拉法辛。在摄入26片50毫克的文拉法辛片剂后，患者出现了一次全身性癫痫发作。她被收治入医学重症监护病房，停用了文拉法辛，未出现进一步的后遗症。
据我们所知，这是首例报告的因文拉法辛过量导致全身性癫痫发作的病例。基于文拉法辛非过量时的药代动力学和药效学以及现有干预措施的潜在风险，未采取紧急治疗。
我们的患者文拉法辛过量导致了单次全身性癫痫发作，但未引发进一步的后遗症。
