Kalynchuk L E, Pinel J P, Treit D, Kippin T E
Department of Psychology, University of British Columbia, Vancouver, Canada.
Biol Psychiatry. 1997 Feb 15;41(4):438-51. doi: 10.1016/S0006-3223(96)00067-4.
The effects of long-term amygdala kindling on emotional behavior were investigated. In Experiment 1, rats received 99 basolateral amygdala, central amygdala, or sham stimulations. The rats in both kindled groups displayed more resistance to capture from an open field and more open-arm activity on an elevated plus maze than did the sham control rats. In Experiment 2, rats received either 20, 60, or 100 amygdala stimulations or sham stimulations. Compared to the sham controls, the kindled rats explored less during the first 30s in a novel open field, avoided the central area of the open field, resisted being captured from the open field, and engaged in more open-arm activity on the elevated plus maze. The magnitude of these effects was greatest in the 100-stim rats and least in the 20-stim rats. Together, these results suggest that long-term amygdala kindling in rats is a useful model for studying the emotionality associated with temporal lobe epilepsy.
研究了长期杏仁核点燃对情绪行为的影响。在实验1中，大鼠接受了99次基底外侧杏仁核、中央杏仁核或假刺激。与假手术对照组大鼠相比，两个点燃组的大鼠在旷场实验中表现出更强的逃避抓捕能力，在高架十字迷宫实验中表现出更多的开放臂活动。在实验2中，大鼠接受了20次、60次或100次杏仁核刺激或假刺激。与假手术对照组相比，点燃组大鼠在新的旷场实验的前30秒内探索行为较少，避开旷场的中央区域，抗拒从旷场中被抓捕，并且在高架十字迷宫实验中表现出更多的开放臂活动。这些效应的程度在接受100次刺激的大鼠中最大，在接受20次刺激的大鼠中最小。总之，这些结果表明，大鼠长期杏仁核点燃是研究与颞叶癫痫相关的情绪性的有用模型。
