Boutros N N, Uretsky N J, Lui J J, Millana R B
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Biol Psychiatry. 1997 Feb 15;41(4):461-6. doi: 10.1016/S0006-3223(96)00057-1.
We have recently reported that acute administration of cocaine to rats alters their sensory inhibitory capacity as tested in a paired click paradigm (S1/S2). Whether such acutely induced changes are persistent, is not known. In order to shed some light on the degree of spontaneous reversibility of cocaine-induced decreased sensory inhibition, rats were tested immediately after cocaine administration and 9 days after cessation of cocaine exposure. Six rats received cocaine HCl 20 mg/kg intraperitoneally and six rats received normal saline for 5 consecutive days. The amplitudes of the S1 responses were significantly decreased in the cocaine animals during the injection days only, but not 9 days later. Two measures of sensory inhibition were employed, S2/S1 x 100 amplitude ratio and S1-S2 amplitude difference. The ratio measure indicated a significant decrease in inhibitory capacity in the cocaine group during the injection days, and remained significantly decreased 9 days after cessation of cocaine administration. The data suggest that repeated cocaine administration can induce persistent deficit in the ability of the rat's brain to inhibit incoming irrelevant sensory stimuli.
我们最近报道，对大鼠急性给予可卡因会改变它们在配对点击范式（S1/S2）测试中的感觉抑制能力。这种急性诱导的变化是否持续尚不清楚。为了深入了解可卡因诱导的感觉抑制降低的自发可逆程度，在给予可卡因后立即以及停止接触可卡因9天后对大鼠进行测试。六只大鼠腹腔注射20mg/kg盐酸可卡因，六只大鼠连续5天接受生理盐水注射。仅在注射可卡因的日子里，可卡因组大鼠S1反应的幅度显著降低，但9天后没有。采用了两种感觉抑制测量方法，即S2/S1×100幅度比和S1 - S2幅度差。比率测量表明，在注射可卡因的日子里，可卡因组的抑制能力显著降低，并且在停止给予可卡因9天后仍显著降低。数据表明，重复给予可卡因会导致大鼠大脑抑制传入的无关感觉刺激的能力持续受损。
