Grunhaus L, Shipley J E, Eiser A, Pande A C, Tandon R, Remen A, Greden J F
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, USA.
Convuls Ther. 1996 Dec;12(4):224-31.
Forty-one patients referred for electroconvulsive therapy (ECT) were evaluated with a standardized clinical protocol and had polysomnographic studies performed pre-ECT after 10 or more days drug free. Clinical evaluations were performed by blind investigators and included the Research Diagnostic Criteria and the Hamilton Rating Scale for Depression (HRSD). Patients were categorized according to the clinical response. Thirty patients (73%) reached a post-ECT HRSD < or = 10, whereas 21 of them (51.2%) reached a post-ECT HRSD score < or = 6. Sleep-onset rapid eye movement (SOREM) periods were present in 27 (66%) of the patients. Few polysomnographic variables differentiated between excellent responders and patients with residual symptoms. Older patients had significantly more disrupted polysomnographic study parameters. Although present in a significant proportion of patients, baseline SOREM was not a factor in outcome.
41名接受电休克治疗（ECT）的患者按照标准化临床方案进行评估，并在停药10天或更长时间后于ECT治疗前进行了多导睡眠图研究。临床评估由不知情的调查人员进行，包括研究诊断标准和汉密尔顿抑郁评定量表（HRSD）。患者根据临床反应进行分类。30名患者（73%）ECT治疗后的HRSD≤10，其中21名患者（51.2%）ECT治疗后的HRSD评分≤6。27名患者（66%）出现睡眠起始快速眼动（SOREM）期。很少有多导睡眠图变量能区分疗效极佳的反应者和有残留症状的患者。老年患者的多导睡眠图研究参数紊乱明显更多。虽然相当一部分患者存在基线SOREM，但它不是影响治疗结果的因素。
