在对电休克治疗反应较差的患者中，电休克治疗后出现睡眠始发快速眼动更为频繁。

Sleep-onset rapid eye movement after electroconvulsive therapy is more frequent in patients who respond less well to electroconvulsive therapy.

作者信息

Grunhaus L, Shipley J E, Eiser A, Pande A C, Tandon R, Krahn D D, Demitrack M A, Remen A, Hirschmann S, Greden J F

机构信息

Department of Psychiatry Sheba Medical Center, Israel.

出版信息

Biol Psychiatry. 1997 Aug 1;42(3):191-200. doi: 10.1016/S0006-3223(96)00333-2.

DOI:10.1016/S0006-3223(96)00333-2

PMID:9232211

Abstract

The response to electroconvulsive therapy (ECT) was monitored with sleep polysomnography studies (SPS) performed pre- and post-ECT, in 25 patients with major depressive disorder (MDD). Patients included in this study met research diagnostic criteria for MDD and had been free of psychotropic medication for at least 10 days before SPS were performed. We compared ECT responders and nonresponders on SPS, demographic, and clinical parameters. Many SPS parameters, regardless of the clinical response, changed significantly with ECT. The presence of delusions was significantly associated with SOREM post-ECT. The presence of sleep-onset REM periods post-ECT was associated with poor response to ECT. SPS performed during a course of ECT may help identify patients at risk of responding less well to this modality of treatment.

摘要

对25例重度抑郁症（MDD）患者在接受电休克治疗（ECT）前后进行睡眠多导睡眠图研究（SPS），以监测其对ECT的反应。纳入本研究的患者符合MDD的研究诊断标准，且在进行SPS前至少10天未服用精神药物。我们比较了ECT反应者和无反应者在SPS、人口统计学和临床参数方面的差异。许多SPS参数，无论临床反应如何，都随ECT有显著变化。妄想的存在与ECT后快速眼动睡眠期（SOREM）显著相关。ECT后出现睡眠起始快速眼动期与对ECT反应不佳有关。在ECT疗程中进行的SPS可能有助于识别对这种治疗方式反应较差的风险患者。