Kilár F
Central Research Laboratory, Medical School, University of Pécs, Hungary.
Electrophoresis. 1996 Dec;17(12):1950-3. doi: 10.1002/elps.1150171224.
Stereoselective interaction of drugs with human serum transferrin in capillary zone electrophoresis is described. The substances passed a pseudo-stationary protein zone applied in a coated capillary and the possible chiral separation of the optical isomers was followed. Drugs with different structures were screened and the enantiomers of bupivacaine, propranolol and promethazine as well as the diastereomers of labetalol were resolved. Racemic mixtures of atenolol and pindolol enantiomers could not be resolved under these conditions.
描述了药物在毛细管区带电泳中与人血清转铁蛋白的立体选择性相互作用。这些物质通过涂覆毛细管中施加的假固定蛋白区，并跟踪光学异构体可能的手性分离。筛选了具有不同结构的药物，布比卡因、普萘洛尔和异丙嗪的对映体以及拉贝洛尔的非对映体得到了分离。在这些条件下，阿替洛尔和吲哚洛尔对映体的外消旋混合物无法分离。
