Trotta M, Morel S, Gasco M R
Dipartimento di Scienza e Tecnologia el Farmaco, Torino, Italy.
Pharmazie. 1997 Jan;52(1):50-3.
Oil/water microemulsions containing benzyl alcohol or different ratios of benzyl alcohol and isopropyl myristate as oil phase were prepared and used as vehicles for the transdermal absorption of felodipine. Skin permeation from the microemulsions was compared with that from a drug suspension in an apparent external phase of a microemulsion and with an aqueous drug suspension. The highest flux was from the microemulsion with the highest solubility of felodipine, while the permeation rate decreased over time from the suspension in the apparent external phase. The flux from the aqueous suspension was 10-50 times lower than that from the microemulsions. These results indicate that microemulsions containing benzyl alcohol may be interesting vehicles for transdermal administration of felodipine.
制备了含有苯甲醇或不同比例苯甲醇与肉豆蔻酸异丙酯作为油相的油/水微乳剂，并将其用作非洛地平透皮吸收的载体。将微乳剂的皮肤渗透情况与微乳剂表观外相中药物混悬液以及水性药物混悬液的渗透情况进行了比较。通量最高的是药物溶解度最高的微乳剂，而表观外相中混悬液的渗透速率随时间下降。水性混悬液的通量比微乳剂低10至50倍。这些结果表明，含有苯甲醇的微乳剂可能是用于非洛地平透皮给药的理想载体。
