氟西汀经皮给药的可行性。
Feasibility of transdermal delivery of fluoxetine.
作者信息
Parikh Darshan K, Ghosh Tapash K
机构信息
Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.
出版信息
AAPS PharmSciTech. 2005 Sep 30;6(2):E144-9. doi: 10.1208/pt060222.
Feasibility of developing a transdermal drug delivery of fluoxetine has been investigated. Permeation studies of fluoxetine across human cadaver skin were carried out using Franz diffusion cells. The receptor phase consisted of pH 7.4 phosphate buffer maintained at 37 degrees C. Permeation enhancement of fluoxetine, either in the salt or base form, was achieved using various enhancers like azone, SR-38, and ethanol. Various O/W microemulsion systems of fluoxetine were developed to study their effect on the skin permeation of fluoxetine. The results indicated that ethanol at 65% vol/vol was able to increase the permeation of fluoxetine the most, while microemulsion systems showed decrease in the permeation of fluoxetine. The permeation of fluoxetine obtained using a 65% vol/vol ethanolic solution was found to be sufficient to deliver the required dose (20-80 mg) from a patch of feasible size. The results seem promising for developing a transdermal drug delivery system of fluoxetine.
已对开发氟西汀透皮给药系统的可行性进行了研究。使用Franz扩散池对氟西汀在人尸体皮肤上的渗透进行了研究。受体相由维持在37℃的pH 7.4磷酸盐缓冲液组成。使用各种促进剂如氮酮、SR-38和乙醇实现了盐形式或碱形式的氟西汀的渗透增强。开发了氟西汀的各种油包水微乳体系以研究它们对氟西汀皮肤渗透的影响。结果表明，65%体积/体积的乙醇能够最大程度地增加氟西汀的渗透，而微乳体系则显示氟西汀的渗透降低。发现使用65%体积/体积乙醇溶液获得的氟西汀渗透足以从可行尺寸的贴片中递送所需剂量（20-80毫克）。这些结果对于开发氟西汀透皮给药系统似乎很有前景。
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