Onodera H, Nishitai R, Shimizu K, Maetani S, Imamura M
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Surg Today. 1997;27(1):60-3. doi: 10.1007/BF01366941.
A case of poorly differentiated adenocarcinoma of the small bowel with extensive lymph node metastases is herein presented, which responded to methotrexate/5-fluorouracil (MTX/5-FU) sequential therapy. The lymph node metastases disappeared completely after 10 months of treatment. After recurrence, combination therapy with radiation, hyperthermia, and cisplatinum were also effective in reducing the degree of nodal swelling while still allowing the patient to maintain her accustomed lifestyle for a prolonged period of time. Further multi-institutional studies are still needed, however, to fully assess this new therapeutic regimen for small bowel cancers.
本文报告一例小肠低分化腺癌伴广泛淋巴结转移患者，其对甲氨蝶呤/5-氟尿嘧啶（MTX/5-FU）序贯疗法有反应。治疗10个月后，淋巴结转移完全消失。复发后，放疗、热疗和顺铂联合治疗在减轻淋巴结肿大程度方面也有效，同时仍能使患者长时间维持其习惯的生活方式。然而，仍需要进一步的多机构研究来全面评估这种针对小肠癌的新治疗方案。
