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[1例晚期胃癌合并弥散性血管内凝血经甲氨蝶呤和5-氟尿嘧啶序贯治疗的病例]

[A case of advanced gastric cancer with DIC treated by sequential MTX and 5-FU].

作者信息

Ohta Shunsuke, Takiuchi Hiroya, Kawabe Shinichiro, Gotoh Masahiro, Hirata Ichiro, Katsu Ken-ichi, Hongo Hitoshi, Fujita Keigo

机构信息

Second Dept. of Internal Medicine, Osaka Medical College.

出版信息

Gan To Kagaku Ryoho. 2004 Mar;31(3):399-401.

PMID:15045948
Abstract

A 75-year-old man was admitted to our hospital complaining of gastric fatigue. Endoscope and CT scan revealed type 3 gastric cancer with paraaortic lymph nodal metastasis. Histological examination of the endoscopic biopsy revealed poorly differentiated adenocarcinoma. A blood examination and bone marrow biopsy revealed DIC causing bone marrow carcinosis. Chemotherapy with sequential therapy consisting of MTX and 5-FU was performed. Stretch of the fold and flatness of the ulcer were obtained against the gastric primary lesion observed endoscopically. Complete response was obtained against the lymph node around the abdominal aorta. Reduction of low back pain and DIC were observed. He was thus able to be discharged and sequential therapy was performed again over 2 months in outpatient care.

摘要

一名75岁男性因胃部乏力入院。内镜检查和CT扫描显示为3型胃癌伴主动脉旁淋巴结转移。内镜活检的组织学检查显示为低分化腺癌。血液检查和骨髓活检显示弥散性血管内凝血导致骨髓癌变。采用甲氨蝶呤和5-氟尿嘧啶序贯疗法进行化疗。在内镜观察到的胃部原发性病变处,褶皱伸展且溃疡变平。腹主动脉周围淋巴结获得完全缓解。观察到腰痛减轻和弥散性血管内凝血情况改善。因此他得以出院,并在门诊进行了为期2个月的再次序贯治疗。

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