一项针对头颈部鳞状细胞癌的随机联合化疗试验，比较含与不含阿霉素的情况。

A randomized combination chemotherapy trial, with and without adriamycin, in squamous cell carcinoma of the head and neck.

作者信息

Shaw H J, Price L A, Hill B T, Calvert A H, Dalley V M, Levene A

出版信息

Otolaryngology. 1978 Nov-Dec;86(6 Pt 1):ORL-845-50. doi: 10.1177/019459987808600602.

DOI:10.1177/019459987808600602

Abstract

One hundred seventeen patients with advanced squamous cell carcinoma of the head and neck were treated and placed randomly between two combination protocols, one with adriamycin and the other without. Responses (more than 50% tumor regression) were 67% overall with 63% responding to the combination without adriamycin and 82% responding to the protocol containing it. The increase in the response rate seen with the addition of adriamycin was not statistically significant. The degree of response to chemotherapy was reduced by prior radiotherapy.

摘要

117例晚期头颈部鳞状细胞癌患者接受了治疗，并被随机分配到两种联合治疗方案中，一种含阿霉素，另一种不含。总体缓解率（肿瘤消退超过50%）为67%，其中不含阿霉素的联合治疗方案缓解率为63%，含阿霉素的方案缓解率为82%。添加阿霉素后缓解率的提高无统计学意义。化疗的缓解程度因先前的放疗而降低。