Büttner H, Rosanowski F, Pottek T, Hartmann M
Abteilung Urologie, Bundeswehrkrankenhaus Hamburg.
Laryngorhinootologie. 1996 Oct;75(10):616-8. doi: 10.1055/s-2007-997644.
Germ cell tumors of the testis usually metastasize to retroperitoneal lymph nodes, lungs, and liver. Other lymphatic or organ metastases especially in the head and neck are rare.
The cases of two men, ages 21 and 35, are presented. In both cases, the histologic examination of cervical lymph node specimen lead to the correct tumor diagnosis of testicular cancer. Multimodal urooncologic therapy led to long-lasting complete remissions in both cases.
In young men between 20 and 35 years of age with cervical metastases of tumors of unknown primary site, germ cell tumors must be suspected. Histologic findings of non-squamous epithelial metastases (seminoma, embryonal carcinoma, chorionic carcinoma, teratoma, yolk sack tumor, and their combined forms) with or without retroperitoneal, mediastinal, or lung metastases; elevated tumor markers (human-chorionic gonadotropin, alpha-feto-protein, placental alkaline phosphatase, lactate dehydrogenase); and palpable intratesticular mass lead to the correct tumor diagnosis. Early detection of the disease is essential for successful therapy and long-term remission.
睾丸生殖细胞肿瘤通常转移至腹膜后淋巴结、肺和肝脏。其他淋巴或器官转移，尤其是头颈部的转移很少见。
介绍了两名男性病例，年龄分别为21岁和35岁。在这两个病例中，颈部淋巴结标本的组织学检查均得出了睾丸癌的正确肿瘤诊断。多模式泌尿肿瘤治疗使两个病例均实现了长期完全缓解。
对于20至35岁不明原发部位肿瘤出现颈部转移的年轻男性，必须怀疑生殖细胞肿瘤。非鳞状上皮转移（精原细胞瘤、胚胎癌、绒毛膜癌、畸胎瘤、卵黄囊瘤及其联合形式）伴或不伴有腹膜后、纵隔或肺转移的组织学发现；肿瘤标志物升高（人绒毛膜促性腺激素、甲胎蛋白、胎盘碱性磷酸酶、乳酸脱氢酶）；以及可触及的睾丸内肿块可得出正确的肿瘤诊断。疾病的早期检测对于成功治疗和长期缓解至关重要。
