Kon' I Ia, Shilina N M, Koterov A N
Biokhimiia. 1996 Jul;61(7):1198-203.
To study possible correlation between plasma transferrin content and level of 2-thiobarbituric acid-reactive substances (malonic dialdehyde (MDA)) in the liver of mice, these parameters were assayed during brombenzol-induced lipid peroxidation and when this process was inhibited by zinc-metallothionein (zinc-MT). In 24 h after brombenzol injection (0.5-2 g/kg intraperitoneally), mice had decreased blood transferrin concentration and increased MDA level in the liver. On the contrary, in 24 h after the zinc-MT injection (1-4 mg/kg intraperitoneally), blood transferrin concentration was 2-3-fold increased and liver MDA content was 2-3-fold decreased. The effects of zinc-MT were observed even in brombenzol-injected animals. Zinc-MT injection increased total transferrin content in the blood and decreased glycosylation of this glycoprotein. Changes in blood transferrin content negatively correlates (r = -0.75) with changes in liver MDA. The data confirm that plasma transferrin can participate in regulation of tissue lipid peroxidation.
为研究小鼠肝脏中血浆转铁蛋白含量与2-硫代巴比妥酸反应性物质（丙二醛（MDA））水平之间的可能相关性，在溴苯诱导的脂质过氧化过程中以及该过程被锌-金属硫蛋白（锌-MT）抑制时，对这些参数进行了测定。溴苯注射（0.5 - 2 g/kg腹腔注射）后24小时，小鼠血液中转铁蛋白浓度降低，肝脏中MDA水平升高。相反，锌-MT注射（1 - 4 mg/kg腹腔注射）后24小时，血液中转铁蛋白浓度升高2 - 3倍，肝脏中MDA含量降低2 - 3倍。即使在注射溴苯的动物中也观察到了锌-MT的作用。锌-MT注射增加了血液中总转铁蛋白含量，并降低了这种糖蛋白的糖基化。血液中转铁蛋白含量的变化与肝脏中MDA的变化呈负相关（r = -0.75）。数据证实血浆转铁蛋白可参与组织脂质过氧化的调节。
