Koterov A N, Shilina N M
Ukr Biokhim Zh (1978). 1995 Jul-Aug;67(4):80-7.
The reduction of malondialdehyde (MDA) content in mouse blood plasma and liver 1h-1 day after the acute ethanol poisoning (3 g/kg) was discovered. Rat liver zinc-metallothionein in a dose 2 mg/kg inoculated before the alcohol introduction restored the MDA level to norm; at the same time the mixture which modulated this protein (albumin, cysteine and zinc) had only the tendency to normalization of the MDA level. On the third day after the poisoning in all cases the 2-2.5 times increase of the plasma MDA level was shown, but the liver MDA content did not change in comparison with the control. The number of the possible explanation of reduction of plasma lipid peroxidation level in the early time after the ethanol poisoning was proposed (hypoxy, aldehyde dehydrogenase activation etc.). It is supposed that zinc-metallothionein influence is connected with its capacity to inactivate acetaldehyde.
发现急性乙醇中毒（3克/千克）后1小时至1天，小鼠血浆和肝脏中丙二醛（MDA）含量降低。在引入酒精前以2毫克/千克的剂量接种大鼠肝脏锌金属硫蛋白可使MDA水平恢复正常；同时，调节这种蛋白质的混合物（白蛋白、半胱氨酸和锌）仅具有使MDA水平正常化的趋势。中毒后第三天，所有情况下血浆MDA水平均升高2 - 2.5倍，但与对照组相比，肝脏MDA含量未发生变化。提出了乙醇中毒后早期血浆脂质过氧化水平降低的多种可能解释（缺氧、醛脱氢酶激活等）。据推测，锌金属硫蛋白的影响与其使乙醛失活的能力有关。
