Yaszemski M J, Payne R G, Hayes W C, Langer R, Mikos A G
Department of Orthopaedic Surgery, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas, USA.
Biomaterials. 1996 Nov;17(22):2127-30. doi: 10.1016/0142-9612(96)00008-7.
We investigated the in vitro degradation of a novel degradable polymeric composite material being developed to function as a temporary replacement for trabecular bone. This material is based on a mixture of poly(propylene fumarate) cross-linked by N-vinyl-pyrrolidone and includes sodium chloride and beta-tricalcium phosphate. Using an in vitro test in simulated body fluids, the compressive strengths and compressive moduli of two composite materials increased with degradation time and remained above the minimum values acceptable for trabecular bone substitutes. A compressive strength of 21.3 (+/- 0.4) MPa and a compressive modulus of 696 (+/- 53) MPa were measured after twelve weeks for a composite material with initial strength of 18.0 (+/- 4.6) MPa and initial modulus of 113 (+/- 40) MPa. This unexpected phenomenon may prove to be useful for orthopaedic applications.
我们研究了一种新型可降解聚合物复合材料的体外降解情况，该材料正被开发用作小梁骨的临时替代品。这种材料基于由N - 乙烯基 - 吡咯烷酮交联的聚富马酸丙二醇酯混合物，并包含氯化钠和β - 磷酸三钙。通过在模拟体液中的体外测试，两种复合材料的抗压强度和抗压模量随降解时间增加，且保持在小梁骨替代物可接受的最小值以上。对于初始强度为18.0（±4.6）MPa和初始模量为113（±40）MPa的复合材料，在十二周后测得抗压强度为21.3（±0.4）MPa，抗压模量为696（±53）MPa。这一意外现象可能对骨科应用有用。
